We have successfully created metastatic cells from their non-metastatic origin, across different solid tumors, e.g. colon and triple-negative breast cancers. Conversely, by CRISPR CAS technology, we have also converted metastatic cells into their non-metastatic counterparts. These cells have helped us establish the differential behaviour of growing and moving cells across the METAssay™ platform and are also fundamental in creating the METVivo™ animal models.